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Credible differences in DNA methylation levels between 3rd—and 4th-generation descendants of Holocaust survivors and non-descendants on FKBP5’s cg08915438 TC21 site ( A ), on NR3C1’s cg21979215 BC21 site ( B ), on CRH’s cg03405789 BC21 site ( C ), and CRHBP’s cg26196496 BC21 site. Descendants of Holocaust survivors exhibited a DNA methylation pattern associated with higher activation of the HPA axis (i.e., lower FKBP5 and CRH, but higher NR3C1 and CRHBP DNA methylation).

Journal: Scientific Reports

Article Title: From trauma to resilience: psychological and epigenetic adaptations in the third generation of holocaust survivors

doi: 10.1038/s41598-025-12085-5

Figure Lengend Snippet: Credible differences in DNA methylation levels between 3rd—and 4th-generation descendants of Holocaust survivors and non-descendants on FKBP5’s cg08915438 TC21 site ( A ), on NR3C1’s cg21979215 BC21 site ( B ), on CRH’s cg03405789 BC21 site ( C ), and CRHBP’s cg26196496 BC21 site. Descendants of Holocaust survivors exhibited a DNA methylation pattern associated with higher activation of the HPA axis (i.e., lower FKBP5 and CRH, but higher NR3C1 and CRHBP DNA methylation).

Article Snippet: An epigenome-wide DNA DNA methylation scan was performed using Illumina’s Infinium ® DNA methylationEPIC v2 BeadChip, providing DNA methylation data across approximately 935,000 sites.

Techniques: DNA Methylation Assay, Activation Assay

Credible differences between 3rd - and 4th -generation descendants of Holocaust survivors and non-descendants in general attachment avoidance ( A ), DNA methylation level on OXT’s cg04731988 TC21 site ( B ), DNA methylation level on OXTR’s cg26455676 BC21 site ( C ), and RyR2’s cg06307043 BC21 site. Descendants of Holocaust survivors exhibited lower general attachment avoidance and a DNA methylation pattern associated with higher oxytocin expression (i.e., lower DNA methylation).

Journal: Scientific Reports

Article Title: From trauma to resilience: psychological and epigenetic adaptations in the third generation of holocaust survivors

doi: 10.1038/s41598-025-12085-5

Figure Lengend Snippet: Credible differences between 3rd - and 4th -generation descendants of Holocaust survivors and non-descendants in general attachment avoidance ( A ), DNA methylation level on OXT’s cg04731988 TC21 site ( B ), DNA methylation level on OXTR’s cg26455676 BC21 site ( C ), and RyR2’s cg06307043 BC21 site. Descendants of Holocaust survivors exhibited lower general attachment avoidance and a DNA methylation pattern associated with higher oxytocin expression (i.e., lower DNA methylation).

Article Snippet: An epigenome-wide DNA DNA methylation scan was performed using Illumina’s Infinium ® DNA methylationEPIC v2 BeadChip, providing DNA methylation data across approximately 935,000 sites.

Techniques: DNA Methylation Assay, Expressing